HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-N-(6-methoxyquinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | N-(6-methoxyquinolin-8-yl)-2-nitrobenzenesulfonamide | HCID 68183106 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | 2-Amino-N-(6-methoxyquinolin-8-yl)-benzenesulfonamide | HCID 68183406 | 68% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, N-(6-methoxyquinolin-8-yl)-2-nitrobenzenesulfonamide (Intermediate 152) (460 mg, 1.17 mmol), tin (II) chloride (886 mg, 4.68 mmol) and 6 N HCl (3 drops) gave the title compound (260 mg, 68%). The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-44545462033248cbb2236cbd161b81b3 |
| Source note | uspto-grants-2015_08 |