HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Amino-N-(5-fluoro-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | N-(5-Fluoro-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide | HCID 68183389 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-N-(5-fluoro-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide | HCID 68183485 | 52% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, N-(5-fluoro-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide (Intermediate 248) (0.42 g, 1.01 mmol), SnCl2 (0.96 g, 5.06 mmol), 6N HCl (cat.) and EtOH (6 ml) at 85° C. for 24 h gave the title compound (200 mg, 52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-f9cdee3e9d7948cebfc2449536ae5b58 |
| Source note | uspto-grants-2015_08 |