Hydrochloric Acid → 2-Amino-N-(5-fluoro-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide

HRID 513556노트

반응식

HRID 513556 반응식
[F:1][C:2]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:17]=2[N+:26]([O-])=O)(=[O:15])=[O:14])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.Cl[Sn]Cl.Cl>CCO>[NH2:26][C:17]1[CH:18]=[C:19]([C:22]([F:24])([F:23])[F:25])[CH:20]=[CH:21][C:16]=1[S:13]([NH:12][C:9]1[CH:10]=[CH:11][C:2]([F:1])=[C:3]2[C:8]=1[N:7]=[CH:6][CH:5]=[CH:4]2)(=[O:14])=[O:15]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24479Stannous ChlorideHCID 68183389N-(5-Fluoro-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide2회

생성물 1

HCID 681834852-Amino-N-(5-fluoro-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide수율 52%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In a similar fashion using route 1 general procedure 4, N-(5-fluoro-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide (Intermediate 248) (0.42 g, 1.01 mmol), SnCl2 (0.96 g, 5.06 mmol), 6N HCl (cat.) and EtOH (6 ml) at 85° C. for 24 h gave the title compound (200 mg, 52%).

후처리

  1. customat 85° C.
  2. customfor 24 h

출처 및 근거

ORD 기록
ord-f9cdee3e9d7948cebfc2449536ae5b58
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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