HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-5-chloro-N-(5-chloro-quinolin-8-yl)-4-fluoro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 5-Chloro-N-(5-chloro-quinolin-8-yl)-4-fluoro-2-nitro-benzenesulfonamide | HCID 68183435 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-5-chloro-N-(5-chloro-quinolin-8-yl)-4-fluoro-benzenesulfonamide | HCID 68183261 | 77% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 5-chloro-N-(5-chloro-quinolin-8-yl)-4-fluoro-2-nitro-benzenesulfonamide (Intermediate 285) (210 mg, 5.0 mmol), SnCl2 (382 mg, 2.0 mmol), 6N HCl (4 drops) and EtOH (5 ml) for 30 h at 90° C. gave the title compound (150 mg, 77%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c9e78c81b2fe4ed293b1957aedcf4cc8 |
| Source note | uspto-grants-2015_08 |