反应详情

In a similar fashion using route 1 general procedure 4, 5-chloro-N-(5-chloro-quinolin-8-yl)-4-fluoro-2-nitro-benzenesulfonamide (Intermediate 285) (210 mg, 5.0 mmol), SnCl2 (382 mg, 2.0 mmol), 6N HCl (4 drops) and EtOH (5 ml) for 30 h at 90° C. gave the title compound (150 mg, 77%) after purification by column chromatography with DCM as the eluent.

1. customfor 30 h
2. customat 90° C.