HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-4-chloro-N-quinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-Chloro-2-nitro-N-quinolin-8-yl-benzenesulfonamide | HCID 23631958 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-4-chloro-N-quinolin-8-yl-benzenesulfonamide | HCID 16759955 | 59.1% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 4-chloro-2-nitro-N-quinolin-8-yl-benzenesulfonamide (Intermediate 263) (280 mg, 0.77 mmol), SnCl2 (383 mg, 3.08 mmol), 6N HCl (2 drops) and EtOH (4 ml) for 6 h at 85° C. gave the title compound (152 mg, 59%) after purification by column chromatography with DCM/MeOH (97:3) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5422d8bb7d9242d9b9e9929b24ec2d1b |
| Source note | uspto-grants-2015_08 |