反应详情

In a similar fashion using route 1 general procedure 4, 4-chloro-2-nitro-N-quinolin-8-yl-benzenesulfonamide (Intermediate 263) (280 mg, 0.77 mmol), SnCl2 (383 mg, 3.08 mmol), 6N HCl (2 drops) and EtOH (4 ml) for 6 h at 85° C. gave the title compound (152 mg, 59%) after purification by column chromatography with DCM/MeOH (97:3) as the eluent.

1. customfor 6 h
2. customat 85° C.