Stannous Chloride → 2-Amino-N-(5-chloro-quinolin-8-yl)-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Stannous Chloride	HCID 24479	—
Reactant	N-(4-Chloro-quinolin-8-yl)-2-nitro-benzenesulfonamide	HCID 68182953	—
Catalyst	Hydrochloric Acid	HCID 313	—
Solvent	Ethanol	HCID 702	—
Product	2-Amino-N-(5-chloro-quinolin-8-yl)-benzenesulfonamide	HCID 68183347	68.5%

Reaction Steps

In a similar fashion using route 1 general procedure 4, N-(5-chloro-quinolin-8-yl)-2-nitro-benzenesulfonamide (Intermediate 246) (600 mg, 1.64 mmol), SnCl2 (940 mg, 4.94 mmol), 6N HCl (5-6 drops) and EtOH (12 ml) at 80° C. for 3 h, gave the title compound (375 mg, 55%) which was used in the next step without further purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09102688B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-1b8ae9304b1b4b9d993ca6277a043d33
Source note	uspto-grants-2015_08