反应详情

In a similar fashion using route 1 general procedure 4, N-(5-chloro-quinolin-8-yl)-2-nitro-benzenesulfonamide (Intermediate 246) (600 mg, 1.64 mmol), SnCl2 (940 mg, 4.94 mmol), 6N HCl (5-6 drops) and EtOH (12 ml) at 80° C. for 3 h, gave the title compound (375 mg, 55%) which was used in the next step without further purification.

1. customat 80° C.
2. customfor 3 h