HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-5-fluoro-N-quinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 5-Fluoro-2-nitro-N-quinolin-8-yl-benzenesulfonamide | HCID 68183277 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-5-fluoro-N-quinolin-8-yl-benzenesulfonamide | HCID 68183146 | 111.8% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 5-fluoro-2-nitro-N-quinolin-8-yl-benzenesulfonamide (Intermediate 267) (0.60 g, 1.72 mmol), SnCl2 (1.31 g, 6.91 mmol), 6N HCl (6 drops) and EtOH (7 ml) gave the title compound (610 mg) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-2ca01afc330d4e04b869fc7bda33496b |
| Source note | uspto-grants-2015_08 |