HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-N-quinolin-8-yl-4-trifluoromethoxy-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 2-Nitro-N-quinolin-8-yl-4-trifluoromethoxy-benzenesulfonamide | HCID 68183243 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-N-quinolin-8-yl-4-trifluoromethoxy-benzenesulfonamide | HCID 68183374 | 75.5% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 2-nitro-N-quinolin-8-yl-4-trifluoromethoxy-benzenesulfonamide (Intermediate 271) (500 mg, 1.21 mmol), SnCl2 (918 mg, 4.84 mmol), 6N HCl (5 drops) and EtOH (10 ml) gave the title compound (350 mg, 75%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7c7c9b0ca139424c8fcadec6d0d0c2ac |
| Source note | uspto-grants-2015_08 |