HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-N-(5-chloroquinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | N-(5-Chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide | HCID 68182997 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-N-(5-chloroquinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide | HCID 68183012 | 92.2% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, N-(5-chloro-quinolin-8-yl)-2-nitro-4-trifluoromethyl-benzenesulfonamide (Intermediate 272) (0.7 g, 1.62 mmol), SnCl2 (0.92 g, 4.86 mmol) and EtOH (15 ml) gave the title compound (0.6 g, 92%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-0fae2770a91541dbb3d50e376ca427be |
| Source note | uspto-grants-2015_08 |