HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butyl nitrite → 1-Trifluoromethyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | 2-Amino-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183487 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-Trifluoromethyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 60164309 | 20.9% |
Reaction Steps
In a similar fashion using route 16 general procedure 61, 2-amino-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 279) (300 mg, 0.82 mmol), t-butyl nitrite (0.14 ml, 1.22 mmol) and AcOH (4 ml) gave the title compound (60 mg, 16%) after purification by column chromatography with DCM/MeOH: aq.NH3 (99:1:2 drops) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-4732581720054db39728949f48095e40 |
| Source note | uspto-grants-2015_08 |