反应详情

In a similar fashion using route 16 general procedure 61, 2-amino-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 279) (300 mg, 0.82 mmol), t-butyl nitrite (0.14 ml, 1.22 mmol) and AcOH (4 ml) gave the title compound (60 mg, 16%) after purification by column chromatography with DCM/MeOH: aq.NH3 (99:1:2 drops) as the eluent.