Benzyl mercaptan → HCID 13788291, compound

HRID 513710Notes

Reaction equation

HRID 513710 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N:3]=1.C([O-])([O-])=O.[K+].[K+].[CH2:15]([SH:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CS(C)=O>[CH2:15]([S:22][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N:3]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 7509Benzyl mercaptanHCID 11430Potassium CarbonateHCID 876016-Chloro-2-picoline

Product 1

HCID 13788291HCID 13788291, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In a similar fashion using route 38 general procedure 92, 2-chloro-6-methylpyridine (1 g, 7.8 mmol), K2CO3 (1.62 g 11.75 mmol), benzylmercaptan (1.46 g 11.8 mmol) and DMSO (7.5 ml) at 150° C. for 4 h in sealed tube gave the title compound (780 mg, 47%) which was used in the next step without further purification.

Workup

  1. customat 150° C.
  2. customfor 4 h

Sources & evidence

ORD record
ord-b9a1d7c6bc4246d5999155d7519cb4e7
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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