HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Fluoro-6-nitrobenzenesulfonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | 2,4-Difluoronitrobenzene | HCID 67967 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Fluoro-6-nitrobenzenesulfonic acid | HCID 12904370 | 22.6% |
Reaction Steps
In a similar fashion using route 39 general procedure 95, 2,4-difluoronitrobenzene (2.0 g, 12.0 mmol) in EtOH (24 ml) and Na2SO3 (3.6 g, 28 mmol) in EtOH:water (32 ml: 40 ml) at 70° C. for 14 h gave the title compound (0.6 g) which was used in the next step without further purification. The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-acb9924702b04996ad46489128e3bbf2 |
| Source note | uspto-grants-2015_08 |