Water → 3-Fluoro-6-nitrobenzenesulfonic acid

HRID 513718Notes

Reaction equation

HRID 513718 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[O-:12][S:13]([O-:15])=[O:14].[Na+].[Na+].O>CCO>[F:8][C:6]1[CH:5]=[CH:4][C:3]([N+:9]([O-:11])=[O:10])=[C:2]([S:13]([OH:15])(=[O:14])=[O:12])[CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24437Sodium SulfiteHCID 679672,4-Difluoronitrobenzene

Product 1

HCID 129043703-Fluoro-6-nitrobenzenesulfonic acidYield 22.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

In a similar fashion using route 39 general procedure 95, 2,4-difluoronitrobenzene (2.0 g, 12.0 mmol) in EtOH (24 ml) and Na2SO3 (3.6 g, 28 mmol) in EtOH:water (32 ml: 40 ml) at 70° C. for 14 h gave the title compound (0.6 g) which was used in the next step without further purification. The structure was confirmed by 1H NMR.

Sources & evidence

ORD record
ord-acb9924702b04996ad46489128e3bbf2
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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