Thionyl Chloride → 1227587-90-7

HRID 513728Notes

Reaction equation

HRID 513728 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[S:14]([OH:17])(=O)=[O:15])([O-:3])=[O:2].S(Cl)([Cl:20])=O>CN(C=O)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[S:14]([Cl:20])(=[O:17])=[O:15])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 86669767HCID 86669767, compound

Product 1

HCID 866697601227587-90-7

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar fashion using route 39 general procedure 96, 2-nitro-5-trifluoromethyl-benzenesulfonic acid 453 (700 mg, 2.58 mmol), thionyl chloride (7 ml) and (0.1 ml) DMF at 90° C. for 3 h gave the title compound (730 mg) which was used in the next step without further purification. The structure was confirmed by 1H NMR.

Workup

  1. customat 90° C.
  2. customfor 3 h

Sources & evidence

ORD record
ord-1142f67e3ddb443ea7ee601bd8bb1824
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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