Stannous Chloride → N'-(8-aminoquinazolin-4-yl)-4-methylbenzene-1-sulfonohydrazide

Participants

Role	Name	HCID	Charge
Reactant	Stannous Chloride	HCID 24479	—
Reactant	4-Methyl-N'-(8-nitroquinazolin-4-yl)benzene-1-sulfonohydrazide	HCID 11462514	—
Catalyst	Hydrochloric Acid	HCID 313	—
Solvent	Ethanol	HCID 702	—
Product	N'-(8-aminoquinazolin-4-yl)-4-methylbenzene-1-sulfonohydrazide	HCID 68183283	67.5%

Reaction Steps

In a similar fashion using route 2 general procedure 4, 4-methyl-N′-(8-nitroquinazolin-4-yl)benzene-1-sulfonohydrazide 478 (100 mg, 0.27 mmol), SnCl2 (310 mg, 1.67 mmol), 6N HCl (1 drop) and EtOH (3 ml) at 80° C. for 3 h gave the title compound (60 mg, 65%) which was used in the next step without further purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09102688B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-ca9f7d2fad424edeb9ae2685fda89bfd
Source note	uspto-grants-2015_08