反应详情

In a similar fashion using route 2 general procedure 4, 4-methyl-N′-(8-nitroquinazolin-4-yl)benzene-1-sulfonohydrazide 478 (100 mg, 0.27 mmol), SnCl2 (310 mg, 1.67 mmol), 6N HCl (1 drop) and EtOH (3 ml) at 80° C. for 3 h gave the title compound (60 mg, 65%) which was used in the next step without further purification.

1. customat 80° C.
2. customfor 3 h