HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → N-(4-Diethylamino-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-(4-Chloro-quinolin-8-yl)-benzenesulfonamide | HCID 68183402 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | N-(4-Diethylamino-quinolin-8-yl)-benzenesulfonamide | HCID 68183484 | 27% |
Reaction Steps
In a similar fashion using route 48 general procedure 114, N-(4-chloro-quinolin-8-yl)-benzenesulfonamide 224 (100 mg, 0.32 mmol), diethyl amine (0.097 ml, 0.94 mmol), DIPEA (0.11 ml, 0.63 mmol) and n-butanol (1 ml) gave the title compound (30 mg, 27%) after purification by column chromatography with chloroform/MeOH (1 drop NH3) (97:3) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-881f307873864ddb811f3156ce05cce5 |
| Source note | uspto-grants-2015_08 |