反应详情

In a similar fashion using route 48 general procedure 114, N-(4-chloro-quinolin-8-yl)-benzenesulfonamide 224 (100 mg, 0.32 mmol), diethyl amine (0.097 ml, 0.94 mmol), DIPEA (0.11 ml, 0.63 mmol) and n-butanol (1 ml) gave the title compound (30 mg, 27%) after purification by column chromatography with chloroform/MeOH (1 drop NH3) (97:3) as the eluent.