反应详情

温度

90 °C

4-Fluoro-2-nitro-N-quinolin-8-yl-benzenesulfonamide 145 (0.13 g, 0.36 mmol) was dissolved in dimethyl amine (2M in THF; 1.77 ml, 3.59 mmol) and the mixture was heated at 90° C. in a sealed tube for 5 h. After cooling, water was added and the mixture was extracted with EtOAc. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (0.13 g, 97%) which was used in the next step without further purification.

1. temperatureAfter cooling
2. extractionthe mixture was extracted with EtOAc
3. dry with materialThe organic phase was dried (Na2SO4)
4. concentrationconcentrated in vacuo