Dimethylamine → 4-Dimethylamino-2-nitro-N-quinolin-8-yl-benzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

4-Fluoro-2-nitro-N-quinolin-8-yl-benzenesulfonamide 145 (0.13 g, 0.36 mmol) was dissolved in dimethyl amine (2M in THF; 1.77 ml, 3.59 mmol) and the mixture was heated at 90° C. in a sealed tube for 5 h. After cooling, water was added and the mixture was extracted with EtOAc. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (0.13 g, 97%) which was used in the next step without further purification.

Provenance & Evidence