HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 12-Chloro-9-piperidin-1-yl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 12-Chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 68183182 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 12-Chloro-9-piperidin-1-yl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 68183454 | 21% |
Reaction Steps
In a similar fashion using route 51 general procedure 118, 12-chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 503 (200 mg, 0.6 mmol), piperidine (195 mg, 2.3 mmol) and NMP (2 ml) gave title compound (50 mg, 21%) after purification by column chromatography using DCM/MeOH (99.5:0.5) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6f3ccd4516254b61b22d263d7d8b5310 |
| Source note | uspto-grants-2015_08 |