HuagongsheHuagongshe Chemistry Print Report · For research reference only
Serinol → 2-(12-Chloro-6,6-dioxo-5,6-dihydro-6lambda*6*-thia-4,5-diaza-chrysen-9-ylamino)-propane-1,3-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Serinol | HCID 68294 | — |
| Reactant | 12-Chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 68183182 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-(12-Chloro-6,6-dioxo-5,6-dihydro-6lambda*6*-thia-4,5-diaza-chrysen-9-ylamino)-propane-1,3-diol | HCID 60164760 | 54% |
Reaction Steps
In a similar fashion using route 51 general procedure 118, 12-chloro-9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide 503 (200 mg, 0.59 mmol), serinol (217 mg, 2.3 mmol) and NMP (2 ml) gave title compound (25 mg, 54%) after purification by column chromatography using DCM/MeOH:aq.NH3 (99.5:0.5:1 drop) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5a97b8ae1991498cb3045693fc87271d |
| Source note | uspto-grants-2015_08 |