HCID 68190304, compound → HCID 68190292, compound

HRID 513785Notes

Reaction equation

HRID 513785 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]([C:17]2[CH:34]=[C:33]3[C:20]([S:21](=[O:37])(=[O:36])[NH:22][C:23]4[C:32]3=[CH:31][C:30]([Cl:35])=[C:29]3[C:24]=4[N:25]=[CH:26][CH:27]=[CH:28]3)=[CH:19][CH:18]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]([C:17]2[CH:34]=[C:33]3[C:20]([S:21](=[O:37])(=[O:36])[NH:22][C:23]4[C:32]3=[CH:31][C:30]([Cl:35])=[C:29]3[C:24]=4[N:25]=[CH:26][CH:27]=[CH:28]3)=[CH:19][CH:18]=2)=[O:16])[CH2:10][CH2:9]1

Participants

4

Reactant 1

HCID 68190304HCID 68190304, compound

Product 1

HCID 68190292HCID 68190292, compoundYield 50.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 12-chloro-6,6-dioxo-5,6-dihydro-6λ*6*-thia-4,5-diaza-chrysene-9-carboxylic acid 1-tert-butoxycarbonyl-piperidin-4-yl ester 534 (70 mg, 0.12 mmol) in 4M HCl in dioxane (3 ml) was stirred at room temperature for 12 h. The solvent was removed in vacuo and the residue was washed with MeOH to give the title compound (27 mg, 47%).

Workup

  1. customThe solvent was removed in vacuo
  2. washthe residue was washed with MeOH

Sources & evidence

ORD record
ord-5b40722c992f4d148bd4d18ed098f695
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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