Ammonia → HCID 68183373, compound

HRID 513788Notes

Reaction equation

HRID 513788 reaction equation
CO[C:3]([C:5]1[C:14]2[C:9](=[C:10]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][CH:6]=1)=[O:4].[NH3:25]>CO>[C:19]1([S:16]([NH:15][C:10]2[CH:11]=[CH:12][CH:13]=[C:14]3[C:9]=2[N:8]=[CH:7][CH:6]=[C:5]3[C:3]([NH2:25])=[O:4])(=[O:17])=[O:18])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 68183202HCID 68183202, compound

Product 1

HCID 68183373HCID 68183373, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar fashion using route 53 general procedure 122, 8-benzenesulfonylamino-quinoline-4-carboxylic acid methyl ester 225 (25 mg, 0.073 mmol) and NH3 in MeOH (7M; 3 ml) gave the title compound (13 mg, 50%) after purification by recrystallisation from DCM.

Sources & evidence

ORD record
ord-161375a6f78d47e4a4e64593c2d3dd25
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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