HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrobenzenesulfonyl chloride → N-(7-Chloro-4-methoxy-quinolin-8-yl)-2-nitro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Reactant | 7-Chloro-4-methoxyquinolin-8-amine | HCID 68183237 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(7-Chloro-4-methoxy-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 68183070 | 56.6% |
Reaction Steps
In a similar fashion using route 18 general procedure 26, 8-amino-7-chloro-4-methoxyquinoline 70 (550 mg, 2.6 mmol), 2-nitrobenzenesulphonylchloride (642 mg, 2.9 mmol) in pyridine (10 ml) gave the title compound (580 mg, 55%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-2b6e02cebae1405eab0651fa35691e82 |
| Source note | uspto-grants-2015_08 |