反应详情

温度

70 °C

10% Pd—C (97 mg) was added to a solution of 2-amino-N-(7-chloro-4-methoxy-quinolin-8-yl)-benzenesulfonamide 570 (470 mg, 1.8 mmol), ammonium formate (571 mg, 9.2 mmol) in 50% AcOH (10 ml) and the mixture was heated to 70° C. for 15 h. After cooling, the solvent was removed in vacuo. The residue was dissolved in EtOAc (100 ml) and the organic phase was washed with sat. NaHCO3 solution (50 ml), dried (MgSO4) concentrated in vacuo. The crude residue was purified by column chromatography DCM/MeOH (99:1) as the eluent to give the title compound (191 mg, 32%).

1. temperatureAfter cooling
2. customthe solvent was removed in vacuo
3. dissolutionThe residue was dissolved in EtOAc (100 ml)
4. washthe organic phase was washed with sat. NaHCO3 solution (50 ml)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo
7. customThe crude residue was purified by column chromatography DCM/MeOH (99:1) as the eluent