反应详情

In a similar fashion using route 2 general procedure 4, 5-methoxy-8-nitroquinoline 585 (550 mg, 2.69 mmol), SnCl2 (1.53 g, 8.08 mmol), 6N HCl (3 drops) and MeOH (15 ml) for 1.3 h at 70° C. for 4 h gave the title compound (430 mg, 91%) which was used in the next step without further purification.

1. customfor 1.3 h
2. customat 70° C.
3. customfor 4 h