HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 12-Methoxy-9-trifluoromethyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | 2-Amino-N-(5-methoxy-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide | HCID 68183365 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 12-Methoxy-9-trifluoromethyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide | HCID 68183336 | 5% |
Reaction Steps
In a similar fashion using route 20 general procedure 61, 2-amino-N-(5-methoxy-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide 588 (440 mg, 1.1 mmol), t-butyl nitrite (0.2 ml, 1.6 mmol), AcOH (4.4 ml) and THF (4.4 ml) gave the title compound (19 mg, 5%) after preparative HPLC (neutral conditions).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-436317256a5842159390ac5c45d4cbbf |
| Source note | uspto-grants-2015_08 |