反应详情

In a similar fashion using route 20 general procedure 61, 2-amino-N-(5-methoxy-quinolin-8-yl)-4-trifluoromethyl-benzenesulfonamide 588 (440 mg, 1.1 mmol), t-butyl nitrite (0.2 ml, 1.6 mmol), AcOH (4.4 ml) and THF (4.4 ml) gave the title compound (19 mg, 5%) after preparative HPLC (neutral conditions).