Hydrochloric Acid → HCID 178432279, compound

HRID 513867Notes

Reaction equation

HRID 513867 reaction equation
[ClH:1].C(=[N:15][NH:16][C:17]1[CH:26]=[C:25]([F:27])[C:20]2[NH:21][C:22]([CH3:24])=[N:23][C:19]=2[CH:18]=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(O)C>[ClH:1].[ClH:1].[F:27][C:25]1[C:20]2[NH:21][C:22]([CH3:24])=[N:23][C:19]=2[CH:18]=[C:17]([NH:16][NH2:15])[CH:26]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178432276HCID 178432276, compound

Product 1

HCID 178432279HCID 178432279, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
61.5 °C

Procedure

Concentrated hydrochloric acid (0.7 ml) was added to a mixture of the crude N-benzhydrylidene-N′-(7-fluoro-2-methyl-1H-benzimidazol-5-yl)-hydrazine (325 mg) and ethanol (0.7 ml). This was stirred at 59 to 64° C. for one hour, and the reaction mixture was cooled to room temperature. Then, the precipitated solid was collected by filtration and dried. Thus, 7-fluoro-2-methyl-1H-benzimidazol-5-yl-hydrazine dihydrochloride (90 mg, 80%) was obtained.

Workup

  1. temperaturethe reaction mixture was cooled to room temperature
  2. filtrationThen, the precipitated solid was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-608b887779d1467aacfe3c34274d82e6
Source dataset
uspto-grants-2015_08
Patent number
US09102692B2

Reaction notes

Loading…