反应详情

温度

80 °C

A mixture of 2,4-dichlorophenylboronic acid (1.0 g), tetrakis(triphenylphosphine)palladium(0) (300 mg), 1-bromo-3-methyl-naphthalen-2-ol (5B, 625 mg) in K2CO3 (2 M, 5.3 mL) and DME (26 mL) was degassed with argon and sealed in a Schlenk tube. The reaction was heated to 80° C. for 75 minutes, then cooled to room temperature. The reaction was diluted with EtOAc and filtered through a pad of silica gel. The silica was washed with EtOAc and the combined organics were concentrated. The crude residue was purified by flash column chromatography (0-18% EtOAc in hexanes) to yield 784 mg of desired product.

1. customwas degassed with argon
2. customsealed in a Schlenk tube
3. temperaturecooled to room temperature
4. additionThe reaction was diluted with EtOAc
5. filtrationfiltered through a pad of silica gel
6. washThe silica was washed with EtOAc
7. concentrationthe combined organics were concentrated
8. customThe crude residue was purified by flash column chromatography (0-18% EtOAc in hexanes)