2-Tert-butoxy-2-(1-(4-chlorophenyl)-4-(3-(dimethylamino)prop-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid → 2-Tert-butoxy-2-(1-(4-chlorophenyl)-4-(3-(dimethylamino)propyl)-3-methylnaphthalen-2-yl)acetic acid
Reaction equation
C(OC(C1C(C)=C(CC)C2C(=CC=CC=2)C=1C1C=CC(Cl)=CC=1)C(O)=O)(C)(C)C.[C:30]([O:34][CH:35]([C:39]1[C:48]([CH3:49])=[C:47]([C:50]#[C:51][CH2:52][N:53]([CH3:55])[CH3:54])[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[C:40]=1[C:56]1[CH:61]=[CH:60][C:59]([Cl:62])=[CH:58][CH:57]=1)[C:36]([OH:38])=[O:37])([CH3:33])([CH3:32])[CH3:31]>>[C:30]([O:34][CH:35]([C:39]1[C:48]([CH3:49])=[C:47]([CH2:50][CH2:51][CH2:52][N:53]([CH3:54])[CH3:55])[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[C:40]=1[C:56]1[CH:57]=[CH:58][C:59]([Cl:62])=[CH:60][CH:61]=1)[C:36]([OH:38])=[O:37])([CH3:33])([CH3:31])[CH3:32]Participants
3
Reactant 2
Product 1
Procedure
2-tert-butoxy-2-(1-(4-chlorophenyl)-4-(3-(dimethylamino)propyl)-3-methylnaphthalen-2-yl)acetic acid (132) was prepared in a manner similar to 2-tert-butoxy-2-(1-(4-chlorophenyl)-4-ethyl-3-methylnaphthalen-2-yl)acetic acid of Example 127, except using 2-tert-butoxy-2-(1-(4-chlorophenyl)-4-(3-(dimethylamino)prop-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid. LCMS-ESI+ (m/z): [M+H]+ calcd for C28H35ClNO3: 468.2; Found: 468.2.
Sources & evidence
- ORD record
- ord-02cceb2e59d541b69f6202162beb77c4
- Source dataset
- uspto-grants-2015_08
- Patent number
- US09102614B2
Reaction notes
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