2-Bromoethyl methyl ether → HCID 86725602, compound

HRID 514483Notes

Reaction equation

HRID 514483 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([OH:8])[CH:7]=1.[CH3:11][O:12][CH2:13][CH2:14]Br>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([O:8][CH2:14][CH2:13][O:12][CH3:11])[CH:7]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 3271485-Chloro-2-(hydroxymethyl)phenol

Product 1

HCID 86725602HCID 86725602, compound

Procedure

The title compound was prepared from 5-chloro-2-(hydroxymethyl)phenol (PREPARATION 7) and 2-methoxyethylbromide according to the procedure for the preparation of Example 111, part A. 1H NMR (400 MHz, CDCl3): δ 3.24 (3H, s), 3.73-3.75 (2H, m), 4.16-4.18 (2H, m), 4.62 (2H, s), 6.87 (1H, d, J=1.6 Hz), 6.93 (1H, dd, J=2.0 Hz, 8.0 Hz), 7.18 (1H, d, J=8.0 Hz).

Sources & evidence

ORD record
ord-19cf5560aab344978d65ec93b8e9e61b
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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