Cyclopropylboronic acid → HCID 86725659, compound

HRID 514553Notes

Reaction equation

HRID 514553 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[F:12].[CH:13]1(B(O)O)[CH2:15][CH2:14]1>>[CH:13]1([C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=2[F:12])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 2760897Cyclopropylboronic acidHCID 21951878Methyl 4-bromo-3-fluorobenzoate

Product 1

HCID 86725659HCID 86725659, compound

Procedure

The title compound was prepared from methyl 4-bromo-3-fluorobenzoate and cyclopropylboronic acid according to the procedure for the preparation of EXAMPLE 152, part A. 1H NMR (400 MHz, CDCl3): δ 0.77-0.81 (2H, m), 1.04-1.09 (2H, m), 2.12-2.16 (1H, m), 3.89 (3H, s), 6.88-6.92 (1H, m), 7.63-7.66 (1H, m), 7.69-7.72 (1H, m).

Sources & evidence

ORD record
ord-b81a73fee8c3458b89d6018ac8c3598f
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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