1-(p-Chlorophenyl)cyclopropanecarboxylic acid → HCID 86725681, compound

HRID 514578Notes

Reaction equation

HRID 514578 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]([OH:13])=O)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[K+].[CH3:15][O:16][C:17](=[O:22])[CH2:18]C([O-])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11](=[O:13])[CH2:18][C:17]([O:16][CH3:15])=[O:22])[CH2:9][CH2:10]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 986061-(p-Chlorophenyl)cyclopropanecarboxylic acidHCID 2724687Potassium methyl malonate

Product 1

HCID 86725681HCID 86725681, compoundYield 78%

Procedure

The title compound was prepared in 78% yield from 1-(4-chlorophenyl)cyclopropane-1-carboxylic acid and 3-methoxy-3-oxopropanoic acid potassium salt according to the procedure for the preparation of Example 170, part A. 1H NMR (300 MHz, CDCl3): δ 1.22-1.26 (2H, m), 1.70-1.74 (2H, m), 3.35 (2H, s), 3.67 (3H, s), 7.29-7.34 (4H, m).

Sources & evidence

ORD record
ord-1b69f5ae26fe456ab10b0dc547848ca9
Source dataset
uspto-grants-2015_08
Patent number
US09107916B2

Reaction notes

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