HCID 90333350, compound → HCID 117720228, compound

HRID 514610Notes

Reaction equation

HRID 514610 reaction equation
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([CH2:22][O:23][CH2:24][C:25]([OH:27])=O)=[O:21])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:28][C:29]1[CH:34]=[CH:33][C:32]([CH:35]([NH:55][C:56]([CH:58]2[CH2:63][CH2:62][C:61]([F:65])([F:64])[CH2:60][CH2:59]2)=[O:57])[CH2:36][CH2:37][N:38]2[CH:43]3[CH2:44][CH2:45][CH:39]2[CH2:40][CH:41]([N:46]2[C:50]([CH3:51])=[N:49][N:48]=[C:47]2[CH:52]([CH3:54])[CH3:53])[CH2:42]3)=[CH:31][CH:30]=1>CN(C=O)C>[CH2:1]([O:8][C:9](=[O:10])[NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:21])[CH2:22][O:23][CH2:24][C:25](=[O:27])[NH:28][C:29]1[CH:30]=[CH:31][C:32]([CH:35]([NH:55][C:56]([CH:58]2[CH2:63][CH2:62][C:61]([F:64])([F:65])[CH2:60][CH2:59]2)=[O:57])[CH2:36][CH2:37][N:38]2[CH:43]3[CH2:44][CH2:45][CH:39]2[CH2:40][CH:41]([N:46]2[C:50]([CH3:51])=[N:49][N:48]=[C:47]2[CH:52]([CH3:54])[CH3:53])[CH2:42]3)=[CH:33][CH:34]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 90333350HCID 90333350, compoundHCID 123844589HCID 123844589, compound

Product 1

HCID 117720228HCID 117720228, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to the general amide coupling procedure by reacting acid 22 with amine 6 in DMF overnight. The crude product was purified with chromatography using CH2Cl2/MeOH (13/1) as eluent to give 260 mg white foaming, in 72% yield. 1H NMR (400 MHz, CDCl3): δ8.96 (s, 1H), 7.57 (d, J=8.48 Hz, 2H), 7.35-7.27 (m, 5H), 7.24 (d, J=8.48 Hz, 2H), 6.75 (m, 1H), 6.70 (m, 1H), 5.12-5.08 (m, 3H), 4.91 (m, 1H), 4.29 (m, 1H), 4.14 (s, 2H), 4.09 (s, 2H), 3.40 (m, 1H), 3.37 (m, 1H), 3.30 (q, J=6.68 Hz, 2H), 3.15 (q, J=6.71 Hz, 2H), 2.99 (m, 1H), 2.48 (s, 3H), 2.43 (t, J=6.48 Hz, 2H), 2.30-2.04 (m, 6H), 2.01-1.71 (m, 8H), 1.70-1.46 (m, 9H), 1.376 (d, J=6.80 Hz, 3H), 1.373 (d, J=6.84 Hz, 3H), 1.35-1.31 (m, 6H); 13C NMR (100 MHz, CDCl3): δ 173.50, 168.64, 167.15, 159.17, 156.55, 150.59, 138.31, 136.66, 136.51, 128.54, 128.12, 128.00, 127.12, 120.51, 77.24, 71.66, 71.50, 66.60, 58.90, 58.30, 51.68, 47.77, 47.24, 42.83, 40.98, 39.14, 35.33, 34.59, 32.82 (J 13C-19F 25.7 Hz), 29.82, 29.36, 28.71, 26.75 (J 13C-19F 10 Hz), 26.48, 25.87, 21.65, 13.15. mp 65-67° C. IR v (Diamond, cm−1): 3273, 1656, 1529, 1515, 1251, 1106, 697. MS (ESI) m/z found 891.9 (M+H)+.

Workup

  1. customThe crude product was purified with chromatography
  2. customto give 260 mg white foaming

Sources & evidence

ORD record
ord-115b709af093423cb1c0707866ad0b7f
Source dataset
uspto-grants-2015_08
Patent number
US09107954B2

Reaction notes

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