反应详情

The obtained 2,2-dimethyl-5-hydroxymethyl-5-[(2-nitro-1H-imidazol-1-yl)methyl]-1,3-dioxane is reacted with p-toluenesulfonyl chloride by for example a method of L. F. Fieser et al. (Reagents for Organic Synthesis, Vol. 1, Wiley, New York, p. 1179 (1967)) and purified, to give the desired 2,2-dimethyl-5-[(2-nitro-1H-imidazol-1-yl)methyl]-5-(p-toluenesulfonyloxymethyl)-1,3-dioxane (FIG. 1, Step 5).

1. customFieser et al. (Reagents for Organic Synthesis, Vol. 1, Wiley, New York, p. 1179 (1967))
2. custompurified