HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-Benzyl-2-hydroxymethyl-4-methoxyindole → n-Benzyl-4-methoxyindole-2-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-Benzyl-2-hydroxymethyl-4-methoxyindole | HCID 22741392 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | n-Benzyl-4-methoxyindole-2-carboxaldehyde | HCID 22739184 | 113.1% |
Reaction Steps
A mixture of 3.2 g of N-benzyl-2-hydroxymethyl-4-methoxyindole (12 mmol) and 15 g of manganese dioxide (172 mmol) in 50 cc of dry dichloromethane was heated at reflux for 6 hours, cooled down to r.t. and filtered through celite. Concentration to dryness afford 3.6 g of a yellow solid. mp.130-31° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713645B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-a48cb8f9a90449699fdf014179d79b09 |
| Source note | uspto-grants-2004_03 |