Hydrochloric Acid → 1-(3,3-Dihydroxymethyl-4-fluorobutyl)-2-nitroimidazole

Participants

Reaction Conditions

Reaction Steps

2,2-Dimethyl-5-fluoromethyl-5-[2-(2-nitro-1H-imidazol-1-yl)ethyl]-1,3-dioxane was dissolved in 0.5 mL of acetonitrile, 0.5 mL of 1 mol/L hydrochloric acid was added thereto, and the mixture was stirred at 80° C. for 30 minutes. After completion of the reaction, the mixture was concentrated under vacuum to give a trace amount of 1-(3,3-dihydroxymethyl-4-fluorobutyl)-2-nitroimidazole.

Provenance & Evidence