Potassium tert-butoxide → HCID 56971610, compound

HRID 514666Notes

Reaction equation

HRID 514666 reaction equation
[CH2:1]([O:8][C:9]([N:11]([CH2:20][C:21]([O:23]CC)=O)[CH2:12][CH2:13][C:14]([NH:16][CH:17]1[CH2:19][CH2:18]1)=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(C)([O-])C.[K+]>C1(C)C=CC=CC=1>[CH:17]1([NH:16][C:14]([CH:13]2[C:21](=[O:23])[CH2:20][N:11]([C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[O:10])[CH2:12]2)=[O:15])[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 86693811HCID 86693811, compound

Product 1

HCID 56971610HCID 56971610, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of ethyl N-benzyloxycarbonyl-N-{(2-cyclopropylaminocarbonyl)ethyl}aminoacetate (200 mg, 0.574 mmol) in toluene (2.0 mL) was added potassium tert-butoxide (136 mg, 1.21 mmol) as a base at an outer temperature set of 40° C., followed by stirring for 2 hours. Then, the HPLC measurement of this reaction mixture was carried out. The results are shown in Table 5.

Sources & evidence

ORD record
ord-7bbb4c8df3694d58a909f46abaf55a9d
Source dataset
uspto-grants-2015_08
Patent number
US09108915B2

Reaction notes

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