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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 514707Generated: October 30, 2026

1-[(Cyclopropylsulfonyl)methyl]-3-nitrobenzene → 3-[(Cyclopropylsulfonyl)methyl]aniline

https://huagongshe.com/reaction/514707

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[(Cyclopropylsulfonyl)methyl]-3-nitrobenzeneHCID 70976459—
Catalysttitanium(III) trichlorideHCID 10313229—
SolventHydrochloric AcidHCID 313—
Product3-[(Cyclopropylsulfonyl)methyl]anilineHCID 86729613—

Reaction Steps

was prepared under similar conditions as described in the preparation of Intermediate 1.3. using 1-[(cyclopropylsulfonyl)methyl]-3-nitrobenzene and titanium(III)chloride solution (about 15%) in about 10% hydrochloric acid (Merck Schuchardt OHG). The batch was purified by chromatography (DCM/EtOH 95:5).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09108926B2
Source datasetuspto-grants-2015_08
ORD IDord-ed332f92eb0049d0b9bec7cb235d452d
Source noteuspto-grants-2015_08