Trifluoroacetic acid → HCID 68852177, compound

HRID 514802Notes

Reaction equation

HRID 514802 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1([OH:18])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([O:3][CH2:4][C:5]1([OH:18])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 722082611-Piperidinecarboxylic acid, 4-(ethoxymethyl)-4-hydroxy-, 1,1-dimethylethyl ester

Product 1

HCID 68852177HCID 68852177, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-(ethoxymethyl)-4-hydroxypiperidine-1-carboxylate (9C, 1 eq.) in DCM was added TFA (10 eq.). The mixture was stirred at r.t. for 0.5 hr, when TLC showed that s.m. was consumed. The mixture was concentrated to give the crude product which was used to the next step without further purification. LC-MS: m/z 160.2 (M+H)+

Workup

  1. customwas consumed
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-2072a15f7fce4db1a1b164648ce4b4d6
Source dataset
uspto-grants-2015_08
Patent number
US09108921B2

Reaction notes

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