Hydrochloric Acid → HCID 90447583, compound

HRID 514817Notes

Reaction equation

HRID 514817 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([OH:21])([CH2:14][C:15]([C:17]([F:20])([F:19])[F:18])=[CH2:16])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[F:20][C:17]([F:18])([F:19])[C:15](=[CH2:16])[CH2:14][C:11]1([OH:21])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 90418966HCID 90418966, compound

Product 1

HCID 90447583HCID 90447583, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl-4-hydroxy-4-(2-(trifluoromethyl)allyl)piperidine-1-carboxylate 17B (300 mg, 0.97 mmol), in DCM (5 mL) was added a solution of HCl in dioxane (3 M, 1 mL, 3 mmol), and then the mixture was stirred at room temperature for 16 hrs. The mixture was concentrated in vacuo to get the desired compound which was used directly for the next step. LC-MS: m/z 210.2 (M+H)+

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-a6b6a757a580478c8d219ff396b43632
Source dataset
uspto-grants-2015_08
Patent number
US09108921B2

Reaction notes

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