3-Aminoquinoline → 3-Fluoroquinoline

Quinolin-3-amine (4 g, 27.7 mmol) was added to HBF4 (26 mL, 48% aqueous solution) portionwise at room temperature, and the mixture was stirred at room temperature until it became homogeneous. The mixture was then cooled to 0° C., and a solution of NaNO2 (2.4 g, 34.8 mmol) in H2O (8 mL) was added dropwise, when the reaction mixture became heterogeneous. The mixture was stirred at 0° C. for 1 hour, then the mixture was filtered, and the filtered cake was washed with cold EtOH, then Et2O. The resulting solid was dried under vacuum, then suspended in toluene in a round bottom flask and was refluxed for 1.5 hours. The resulting mixture was cooled to room temperature, and then poured into cold water. The organic layer was dried over Na2SO4, and then concentrated in vacuo to obtain the desired product (1.6 g). LC-MS: m/z 148.1 (M+H)+

1. temperatureThe mixture was then cooled to 0° C.
2. stirringThe mixture was stirred at 0° C. for 1 hour
3. filtrationthe mixture was filtered
4. washthe filtered cake was washed with cold EtOH
5. customThe resulting solid was dried under vacuum
6. customsuspended in toluene in a round bottom flask
7. temperaturewas refluxed for 1.5 hours
8. temperatureThe resulting mixture was cooled to room temperature
9. additionpoured into cold water
10. dry with materialThe organic layer was dried over Na2SO4
11. concentrationconcentrated in vacuo

ORD record

ord-28ac9751e0624fa4b5b21bb1223fcf4c

Source dataset

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09108921B2