Methyl 2-cyano-4-nitrobenzoate → Methyl 4-amino-2-cyanobenzoate

HRID 514843Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 514843
[C:1]([C:3]1[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6])#[N:2]>CO.[Pd]>[NH2:13][C:11]1[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[C:3]([C:1]#[N:2])[CH:12]=1

Komponenten

4

Edukt 1

HCID 10104417Methyl 2-cyano-4-nitrobenzoate

Produkt 1

HCID 53419668Methyl 4-amino-2-cyanobenzoateAusbeute 99,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-cyano-4-nitrobenzoate (0.9 g, 4.4 mmol) in MeOH (5 mL) was added Pd/C (0.1 g). The resulting mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. The mixture was filtered, and the filtrate was evaporated to dryness under reduced pressure to give the title product (0.77 g), which was used in the next step without further purification. LC-MS: m/z 177.2 (M+H)+

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-767d51c8b7ea47d098a48e802e108cd7
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09108921B2

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