HCID 90419025, compound → HCID 90418931, compound

HRID 514851Notes

Reaction equation

HRID 514851 reaction equation
[F:1][CH:2]([F:19])[CH2:3][CH2:4][C:5]1([OH:18])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1>Cl.O1CCOCC1>[F:19][CH:2]([F:1])[CH2:3][CH2:4][C:5]1([OH:18])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 90419025HCID 90419025, compound

Product 1

HCID 90418931HCID 90418931, compoundYield 156.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 4-(3,3-difluoropropyl)-4-hydroxypiperidine-1-carboxylate (293 mg, 1.075 mmol) in 5 mL of 3.5 N HCl in dioxane was stirred at r.t. for 30 min. The reaction mixture was concentrated in vacuo to give 301 mg of the title product which was used in the next step directly.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-e361e40b7e01445a93fbb01137c281b5
Source dataset
uspto-grants-2015_08
Patent number
US09108921B2

Reaction notes

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